Mano attended the University of Glasgow in 1886-1887 to study Science and Engineering, having previously studied and taught in Japan. he then worked at WG Armstrong & Company before returning to Japan in 1889. Back in Japan he was appointed Professor of the Faculty of Technology at the Imperial University, and was also responsible as Examiner of the Patent Office. In 1901, the Japanese Government appointed Mano to Director of School Affairs at the Ministry of Education. 1913-1926, he was appointed President of Kyushu Imperial University. In 1927, Mano was elected to serve as a member of the Japanese House of Lords and also served as Privy Councillor in 1939.
He and Tsuneta Shin were our first Japanese members.